Laboratory studies

Photosafety and photoxicity

Our team has expertise in performing in vitro phototoxicity studies to examine the phototoxic properties of investigational compounds in experimental models – usually human cell cultures in concordance with current regulatory guidelines. Our specialist laboratory services include:

  • Spectral analysis and photostability studies
  • Action spectra and wavelength dependence
  • Phototoxicity assessment such as with the neutral red uptake phototoxicity assay.
  • Spectratox can also offer supplementary assays including photo-comet assay that examines DNA damage induced by UV radiation.

Photophysics and light source evaluation

At Spectratox, we place high value on dosimetry – the science of accurate measurement. The result of this background activity may be summed in one word, “Confidence”. Knowledge of the light dose administered to subjects during testing is fundamental to the reliability of the results obtained. The team at Spectratox has an international reputation in the field of UV and visible light measurement. All measurements are traceable to the national measurement institutes – the National Physical Laboratory (UK) and the Laboratoire National de Metrologie et d’Essais (France). Equipment used by Spectratox has been designed and built according to our own specification, relying on our many years of experience of drug phototesting allied to our knowledge of the latest developments in optics. Calibrations are performed in-house in an optical radiation laboratory accredited to ISO 17025:2005 by the United Kingdom Accreditation Service (UKAS). Accreditation by UKAS demonstrates competence, impartiality and performance capability of the laboratory. All of the work carried out by Spectratox is underpinned by strict adherence to quality control. In addition to drug phototoxicity clinical trial support, the Photophysics section of Spectratox can provide:

  • Calibration of ultraviolet (ISO 17025) and visible light measurement equipment
  • Risk assessment of devices emitting optical radiation
  • Trials in volunteers for manufacturers of lasers, LEDs and other light sources, including home-use devices.